1. (China Daily) China's listed banks are ramping up the adoption of artificial intelligence, accelerating deployments in the first half as they seek to boost efficiency, enhance customer experience and unlock new growth, with experts saying large AI models are shifting from tools of productivity to engines of value creation.  

    During its 2025 interim results briefing on Aug 29, Han Jing, executive vice-president of China Construction Bank, said: "We use technology and data-driven approaches, especially AI, to empower precise customer identification, targeted marketing and accurate profiling. This is reflected in both our corporate and retail business segments. By gaining insights into customer characteristics, we can precisely tailor our products and services."  

    In corporate banking, CCB managed long-tail clients through robotic tools, adding over 130 billion yuan ($18.3 billion) in new corporate deposits in the first half. In retail banking, its intelligent management helped achieve a nearly 95 percent renewal rate for maturing deposits, said Han.

    Industrial and Commercial Bank of China introduced over 100 new AI-powered application scenarios across key business areas such as personal finance, financial markets and corporate lending, including an AI wealth assistant and an intelligent investment research assistant.  

    Postal Savings Bank of China has developed more than 230 large-model application scenarios. Its interbank ecosystem platform has deployed bill-transaction robots, achieving full-process intelligent management across all bill types. Its investment banking transaction robots enable intelligent inquiry and response for bond underwriting, boosting inquiry efficiency by more than 95 percent. The lender's intelligent loan review assistants support over 30,000 loan approval cases daily by effectively identifying, extracting and classifying more than 10 types of images, thereby further improving loan review efficiency.  

    While large State-owned banks maintain leadership in applying digital technologies, joint-stock commercial lenders are also striving to catch up.

    In the first half, China Everbright Bank launched a large-model intelligent policy assistant, building a knowledge base of over 1,700 policy documents and an intelligent policy search and analysis agent. By linking policy documents with business scenarios, it has improved compliance execution and built end-to-end policy service capabilities.  

    Bank of Beijing, embracing an "All in AI" strategy, is accelerating its transformation into an AI-driven commercial bank. It has established an AI system built on an integrated computing power infrastructure and developed two major model development and operating platforms.  

    Huo Xuewen, chairman at Bank of Beijing, said the integrated computing power base allows unified management of enterprise-level AI resources, significantly improving operational efficiency and enhancing data linkage and analytical capabilities. The two platforms, driven by both large and small models, empower product innovation, customer service and risk management. The bank has developed a core AI capability system with over 100 AI functions, rolled out a suite of practical AI tools and built more than 300 application scenarios.

    Ping An Bank's interim report showed that in the first half, the lender built a large-model capability system, refining models through supervised fine-tuning, autonomous large-model planning and intelligent agents to enhance application capabilities in key scenarios. As of the end of June, it had deployed over 330 large-model application scenarios.  

    Beyond business applications, digital finance is also playing an increasingly important role in risk management and compliance. For example, in corporate risk management, Ping An Bank has deepened its exploration of intelligent risk control protocols powered by large models, building a knowledge base of risk experts and leveraging intelligent systems to improve the efficiency of risk-control processes and broaden the applicability of large models.  

    In retail loan approvals and collections, the bank relies on large-model capabilities to extract and identify risk characteristics from unstructured data and other elements.

    Industry experts point out that the use of large AI models in risk management remains at an exploratory stage. Looking ahead, in order to better ensure security, AI large models are expected to gradually unlock greater value in forward-looking risk identification, accuracy of risk assessment, speed of risk monitoring and breadth of risk management.

    Source: By Jiang Xueqing | China Daily | Updated: 2025-09-19 09:04

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  2. (AP) President Donald Trump said prominent billionaires – including media mogul Rupert Murdoch and tech founder Michael Dell – could be part of a deal in which the U.S. will take control of the social video platform TikTok.  

    Trump name dropped the 94-year-old Murdoch and his son Lachlan Murdoch, the head of Fox News and News Corp, as part of a group of possible participants in a deal during an interview recorded Friday and aired Sunday on Fox News.  

    “I think they’re going to be in the group. A couple of others. Really great people, very prominent people,” Trump said. “And they’re also American patriots, you know, they love this country. I think they’re going to do a really good job.”  

    Trump’s disclosure of the potential involvement of the Murdochs and Dell, the founder and CEO of Dell Technologies, is the latest twist in a fast-moving potential deal to keep TikTok operating in the U.S.

    Trump also said Sunday that tech giant Oracle founder and CEO Larry Ellison was part of the same group. His involvement had been previously disclosed. On Saturday, White House press secretary Karoline Leavitt said Oracle would be responsible for the app’s data and security and that Americans will control six of the seven seats for a planned board.

    Much is still unknown about the actual deal in the works. Trump discussed the TikTok deal with China’s Xi Jinping in a lengthy phone call on Friday. Chinese and U.S. officials have until Dec. 16 to hash out the details, following the latest deadline extension by the Trump administration.  

    TikTok is a hugely popular app currently owned by a Chinese company, ByteDance. American officials have warned the algorithm TikTok uses to shape what users see is vulnerable to manipulation by Chinese authorities, who can use it to push content on the platform in a way that’s difficult to detect.  

    Congress passed legislation calling for a TikTok ban to go into effect in January, but Trump has repeatedly signed orders that have allowed TikTok to keep operating in the United States as his administration tries to reach an agreement for the social media company’s parent company to sell its U.S. operations.

    On Sunday, Trump said that he was “a little prejudiced” about TikTok because he credited the app for helping him connect with young voters. Trump said slain conservative activist Charlie Kirk encouraged the president to use the app.  

    Representatives for Ellison, Dell and the Murdochs could not immediately be reached for comment.  

    Trump filed a lawsuit against Murdoch and one of his newspapers, The Wall Street Journal, in July after it published a story reporting on the president’s ties to wealthy financier and convicted sex offender Jeffrey Epstein.

    Source: Associated Press by Alan Suderman  Updated 10:58 AM PDT, September 21, 2025

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  3. (China Daily) The National Healthcare Security Administration on Saturday released the rules for the 11th round of its national drug centralized procurement program, focusing on ensuring clinical supply, guaranteeing drug quality and countering market involution.  

    Launched in 2018, the national bulk-buy program aims to reduce the financial burden on patients by having pharmaceutical manufacturers participate in a competitive bidding process, lowering prices and securing large-volume contracts with major public hospitals.  

    To better align with clinical needs, the administration said during the latest round, medical institutions can report their procurement requirements either by generic drug name — as was previously the practice — or by specifying preferred brands.

    If a hospital's preferred brand wins the bid, the corresponding manufacturer will supply the product directly to that institution.  

    About 46,000 medical institutions participated in this round of demand reporting, with 77 percent specifying brands, the administration said.  

    In addition, the administration has adjusted pricing comparison rules for small-volume pediatric drugs to encourage the supply of low-dosage medications tailored for children.

    To further ensure the quality of selected drugs, higher standards will be applied to the quality control capabilities of bidding enterprises, with priority given to manufacturers with broad clinical recognition and consistent quality records.  

    The administration stressed maintaining an open, transparent, fair and market-oriented competition mechanism and "taking a firm stance against excessive involution". 

    Companies are required to submit bids no lower than their production costs, and any bid below a pre established anchor price — determined by experts and regulatory authorities — must be justified to address public concerns over abnormally low-priced bids.  

    The past ten rounds of the national centralized drug procurement program have covered 435 types of medicines, achieving an average price cut of 50 percent.

    Source: By Wang Xiaoyu | chinadaily.com.cn | Updated: 2025-09-21 14:02

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  4. (China Daily) China's top market regulator said on Friday that it has opened an investigation into Chengdu Kuaigou Technology Co, the e-commerce subsidiary of Kuaishou, for suspected violations of the country's e-commerce law. Beijing is currently stepping up its regulation of the fast-growing livestreaming industry.  

    The State Administration for Market Regulation said the decision followed a preliminary review of the company and is part of efforts to promote the healthy development of the platform economy and safeguard consumer rights.

    Source: By Cheng Yu | chinadaily.com.cn | Updated: 2025-09-19 21:45

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  5. (China Daily) Focusing on AI quantum and quantum intelligence, a forum drew experts from home and abroad to discuss pressing scientific challenges and emerging opportunities in the field of quantum artificial intelligence, as well as to explore future industrial applications in Shanghai's Zhangjiang Science City on Sunday.  

    Participants from countries, including China, the United States, the Netherlands, Luxembourg, and Singapore, engaged in academic presentations and roundtable discussions at the event, which was part of the 18th Pujiang Innovation Forum. Their key topics included the intersection of AI with atomic quantum computing, quantum information science, quantum circuit optimization, and the application of quantum algorithms.  

    While AI development is advancing rapidly, it increasingly faces limitations due to classical computational power constraints. Quantum computing, however, shows immense potential for overcoming these limitations, according to the experts. Researchers are actively exploring ways to leverage quantum computing to accelerate machine learning training, reduce computational costs, and enhance model expressiveness.

    Scientists at the forum expressed optimism that with continued advancements in quantum hardware and algorithms, quantum AI is expected to revolutionize fields such as drug discovery and financial modeling.  

    During the forum, the joint quantum AI initiative of Shanghai was announced. This initiative comprises 12 research institutions, including Fudan University, the Shanghai Qi Zhi Institute, the Shanghai Research Center for Quantum Sciences, and the Shanghai Artificial Intelligence Laboratory, alongside several leading quantum technology enterprises. Li Xiaopeng, a professor from Fudan University's department of physics, said that over the next five years, the initiative will focus on interdisciplinary research in quantum AI, aiming to break through foundational theories, key technologies, and major applications while nurturing high-level talent in the field.  

    Additionally, the forum saw the release of Shanghai's top 10 quantum computing application scenarios, spanning sectors from electricity to finance, logistics, new energy, and biomedicine. These scenarios not only address practical application needs but also highlight the potential of quantum technologies to solve complex problems and drive future industrial transformation, said experts.

    Andrew Chi-Chih Yao, an academician with the Chinese Academy of Sciences and dean of the Institute for Interdisciplinary Information Sciences at Tsinghua University, said that China is at the world's forefront of applying AI in fields like robotics and materials science.  

    "The progress in various electronic industries will undoubtedly stem from quantum technology. In this era of fast-paced technology development, we must have foresight and vision to undertake initiatives that will be leading even a decade from now," he said.

    Source: By Zhou Wenting in Shanghai | chinadaily.com.cn | Updated: 2025-09-22 10:36

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  6. (China Daily) At a textile mill in Suzhou, Jiangsu province, the rhythmic clatter of looms is now harmonized with a new sound: the silent, rapid-fire calculations of artificial intelligence.  

    China Telecom's "StarWeave Textile AI Agent" is relentlessly at work here — adjusting thread tension in real-time and scrutinizing fabric for flaws as it emerges, transforming an age-old craft in the process.  

    The results speak volumes: 99 percent on-time delivery, a 20 percent surge in productivity and near-perfect defect detection, China Telecom said.

    This is not an isolated experiment, but a glimpse into a sweeping transformation where AI is rapidly becoming the indispensable engine powering China's industrial evolution.  

    Across the vast landscape of Chinese manufacturing, a wave of "Industry plus AI" is cresting, driven by the nation's tech companies, which are scrambling to develop AI agents to solve tasks.  

    AI agents are software systems that use AI to pursue goals and complete tasks on behalf of users. Unlike traditional AI, which may simply assist or provide recommendations, AI agents are capable of executing complex workflows without continuous human input. These agents are purpose-built to perform specialized roles within a company, such as customer support, data analysis, compliance checking or even performing financial tasks, experts said.

    Li Lecheng, minister of industry and information technology, chaired a meeting in Beijing in June, outlining a comprehensive strategy to accelerate AI technological innovation and integrated application, thereby positioning AI as a core driver of China's new industrialization.  

    Xie Shaofeng, chief engineer at the Ministry of Industry and Information Technology, the country's top industry regulator, said at a news conference that the ministry has also coordinated with provincial governments to develop 11 national AI innovation pilot zones.  

    Meanwhile, central and local authorities have jointly built specialized manufacturing innovation centers for embodied AI robots, humanoid robots and other next-generation technologies to drive the development of industrial clusters, Xie said.

    Hong Qunlian, a researcher at the National Development and Reform Commission's Chinese Academy of Macroeconomic Research, said: "Manufacturing is the focal point of competition among major powers and technological supremacy. Nurturing strategic advantages for the future fundamentally relies on the high-quality development of our manufacturing industry.  

    "Promoting AI-driven industrial upgrading is paramount for China's real economy over the next five years. And, achieving breakthroughs in critical technologies is not optional, it is essential, as we still face challenges in these areas."  

    Ryoji Sekido, co-CEO of Accenture Asia Pacific, said: "China stands at the forefront of global AI innovation and deployment, serving as an unparalleled benchmark for enterprise transformation.  

    "There is no better place to witness AI progress than right here in China and Shanghai. The ecosystem's rapid evolution is impressive."

    Sekido highlighted how Chinese companies are transitioning from isolated AI experiments to comprehensive, enterprise-wide reinvention. He pointed to electric vehicle giant BYD as a paradigm-shifting case.  

    "This isn't about simple AI use cases. BYD harnessed AI end-to-end — from battery R&D and design automation to manufacturing and autonomous driving systems — fundamentally reinventing operations to accelerate time-to-market and capture dominant market share," Sekido said.  

    This approach, he stressed, represents "corporate reinvention", where AI becomes a strategic engine rather than a productivity tool.

    The statistics also confirm the surge.  

    Market research company International Data Corp revealed a seismic shift: the proportion of Chinese industrial enterprises deploying large models and intelligent agents has skyrocketed from 9.6 percent in 2024 to 47.5 percent in 2025.  

    Crucially, those implementing these technologies across multiple operational areas have exploded from 1.7 percent to 35 percent.  

    "We're moving rapidly beyond isolated pilots," said Cui Can, senior research manager of IDC China. "High-value intelligent agent applications are landing and scaling."

    IDC forecasts China's industrial AI spending to reach 90 billion yuan ($12.53 billion) by 2028, fueled by this accelerating adoption.  

    This is far more than mere automation.  

    AI is enabling a fundamental evolution in how Chinese industry operates, moving from fragmented point solutions toward interconnected, increasingly autonomous systems. "Industrial AI agents represent a critical lever," Cui said. "They drive the innovation cycle for essential industrial assets — datasets and large language models — creating a self-reinforcing ecosystem for advancement."

    The applications are diversifying rapidly across the industrial landscape.  

    In May, Lenovo unveiled its manufacturing-focused AI agents, designed to fuse AI capabilities with decades of industrial know-how. Its "Supply Chain Control Tower" agent delivers staggering efficiency: decision-making accelerated by 50-60 percent, order fulfillment rates boosted by 5 percent, and a 20 percent reduction in manufacturing and logistics costs, Lenovo said.

    The momentum is palpable.  

    Huawei entered the fray in June with FusionPlant 3.0, a strategic platform explicitly designed to accelerate the creation and deployment of industrial AI agents and smart applications.  

    The message from these companies is unequivocal: industrial AI is no longer speculative; it's operational, delivering concrete value.

    Concurrently, companies like Shanghai Wisdom Information Technology Co Ltd are pioneering "industrial AI agents codriven by large language models", creating novel digital applications and multimodal AI cooperation specifically designed for manufacturing environments, focusing on end-to-end optimization.  

    Sector-specific revolutions are also unfolding, exemplified by Dongfang Precision Group's subsidiary, which is laser-focused on AI-driven transformation for the packaging industry, offering tailor-made industrial internet platforms and digital upgrade solutions.  

    Despite the impressive strides, the path forward demands more than isolated technological triumphs. Industry leaders and analysts alike stress that the next phase of industrial AI maturity hinges on robust ecosystem collaboration to overcome persistent hurdles.  

    The challenges, however, are multifaceted and deeply interconnected. Data fragmentation remains a major barrier, with inconsistent data hindering AI's full potential, and breaking down these walls necessitates industry-wide standards and cooperation, experts said.

    Meanwhile, significant technological hurdles persist, including the limited generalization capabilities of large models while tackling highly specific, complex industrial tasks, and the critical bottleneck of computational power. "Computing power scarcity fundamentally constrains development. Yet utilization efficiency in training and inference is often paradoxically low," said Cao Kai, director of Smart Industrial Solutions at Baidu Smart Cloud.  

    The transformation is undeniable. From Lenovo's streamlined global supply chain to the flawless fabric rolling off AI-monitored looms, intelligent agents are demonstrably enhancing productivity, slashing costs, and enabling unprecedented precision.  

    As these agents proliferate, learning and adapting within complex industrial ecosystems, they are evolving from sophisticated tools into the very central nervous system of modern Chinese manufacturing, experts added.

    "Innovation stands as a pivotal force propelling the high-quality advancement of the manufacturing sector, and companies are increasingly assuming central roles in driving innovation," said Li Jinghong, an academician at the Chinese Academy of Sciences and a professor at Tsinghua University.  

    Ma Jun, senior vice-president of Volvo Group and president of Volvo (China) Investment, said: "We see great potential in China's AI growth. With its vast market and diverse application scenarios, China provides a unique space for AI innovation. I look forward to seeing more creative AI solutions in the transportation and infrastructure sectors, to help reduce logistics costs further and support sustainable development in China and globally."

    Source: By Ma Si | China Daily | Updated: 2025-08-18 07:34

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  7. (Xinhua) Across China's steel industry, once noisy furnace floors are giving way to intelligent systems where control centers analyze vast streams of production data in real time, artificial intelligence (AI) adjusts furnace temperatures dynamically, and robots spot defects with greater accuracy.  

    For industry veterans, this transformation is striking, and experts say it signals how frontier technologies are breathing new life into traditional sectors.  

    "As a frontier technology in the digital era, AI is bringing new hope to breaking long-standing bottlenecks in the steel industry," said Zhang Longqiang, head of the China Metallurgical Information and Standardization Institute, adding that intelligent algorithms are already driving progress in process optimization, quality control and supply chain management.

    Figures from the China Iron and Steel Association show that 95.1 percent of Chinese steel enterprises have incorporated digital transformation strategies into their overall development plans, 82.9 percent have established centralized intelligent control centers, and 63.4 percent have applied 3D visualization and simulation systems to build digital factories.  

    Steelmakers are also using AI to advance their green transition. HBIS Group's upgraded carbon-neutral digital platform -- designed as a multifunctional and multi-scenario intelligent system -- enables accurate energy consumption forecasting and can double the efficiency of carbon-allowance demand analysis.  

    Looking ahead, Wang Guodong, an academician of the Chinese Academy of Engineering, said that the steel industry should accelerate the integration of industrial internet, big data and AI technologies; move from end-of-pipe treatment to source control and whole-process management featuring human-machine collaboration and autonomous, unmanned operations; and achieve coordinated progress in cutting carbon emissions, reducing pollution, expanding green development and sustaining growth.

    From factory floors to farmlands and services hubs, China's "AI Plus" drive is expanding across the economy. Drones streamline logistics in Shenzhen, AI-powered robots help manage greenhouses in Shandong, and intelligent voice systems in Hefei serve users around the world. Together, these snapshots of China's AI landscape underscore the country's strengths in its rich data resources, complete industrial system and broad application scenarios.  

    The State Council recently unveiled a set of guidelines on advancing the "AI Plus" initiative, providing a systematic action plan to embed AI into various sectors and support high-quality social and economic development.  

    Experts say the initiative marks a new stage of the digital revolution. Zhong Xinlong, a researcher at the China Center for Information Industry Development, used a vivid analogy: If the last decade was about building an extensive information superhighway, the next decade will be about running countless fleets of intelligent agents with decision-making and collaborative capabilities on that highway.

    The guidelines propose support for the construction of open-source AI communities, and for the pooling and opening of models, tools and datasets to be promoted, which will provide the key needs of technological innovation and will lower research and development barriers.  

    Yan Yijun, vice president of AI unicorn MiniMax, said this will offer a solid foundation for technology-driven enterprises to carry out research and development, providing development guidance and market space for the expansion of industry solutions and participation in the intelligent transformation of traditional industries, while also creating more business opportunities and accelerating global cooperation.  

    According to the National Development and Reform Commission, which is the country's top economic planner, the implementation of the "AI Plus" initiative will involve introducing supporting policies and accelerating the development of standards across different sectors and industries. This will promote major projects such as the development of AI vouchers, and foster demonstration cases by guiding AI model developers, research institutes and leading enterprises to form cross-disciplinary teams, while encouraging local governments and companies to explore new development models.

    Launching the initiative is not only a key step to fostering new quality productive forces but also an inevitable requirement to drive the digital economy toward an intelligent economy and an intelligent society, said Huo Fupeng, director of the commission's innovation-driven development center.  

    As industry experts have noted, what truly transforms society is not technology itself but the depth and breadth of its integration into production and everyday life. As AI penetrates a wide range of industries in China, and as innovation thrives under sound institutional support, a systemic restructuring of the country's economic and social development is gaining pace.

    Source: Xinhua  2025-09-04 20:52:00

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  8. (Reuters) A U.S.-China agreement on TikTok's U.S. operations includes China's ByteDance choosing one of seven board members for the new entity, with Americans holding the six other seats, a senior White House official said on Saturday. 

    President Donald Trump is trying to keep the short video app with 170 million U.S. users from being banned after Congress passed a law in 2024 that ordered it shut down by January 2025 if its U.S. assets were not sold by owner ByteDance.

    Trump has delayed enforcement of the law through mid-December amid efforts to extract TikTok's U.S. assets from the global platform, line up American investors and ensure the new ownership qualifies as a full divestiture needed under the 2024 law. 

    This week's progress toward a deal marked a rare breakthrough in months-long talks between the world's two biggest economies that have sought to defuse a wide-ranging trade war that has unnerved global markets. 

    Trump said on Friday that he and Chinese President Xi Jinping had made progress on a TikTok agreement in a phone call and would meet face-to-face in six weeks. But Beijing's statements have not clarified how advanced the progress has been.

    Details of the agreement, as laid out by the senior White House official, largely align with reporting from Reuters and other news outlets in recent days. The official said Trump would extend the latest pause in enforcement of the 2024 law for an additional 120 days, suggesting the next deadline for an agreement to be finalized would be in April. 

    TikTok, China's Ministry of Commerce, and the Cyberspace Administration of China did not respond to requests for comment. 

    Still, lawmakers will want an explanation about how the deal will work. 

    "The devil will be in the details," said Representative Frank Pallone, a Democrat. "We cannot allow China continued access to massive amounts of Americans’ personal data, and we cannot allow Trump to hand TikTok over to his tech bro buddies and turn it into a MAGA mouthpiece. Period."

    It is not clear if the deal in its current state will qualify as a full divestiture as required by Congress under the 2024 law. 

    Trump has credited TikTok with helping him win re-election last year and has 15 million followers on his personal account. The White House also launched an official TikTok account last month. 

    The agreement described by the official, as expected, will require that all data on American users will be stored on U.S. cloud computing infrastructure run by U.S. software firm Oracle.

    The official also said the TikTok algorithm "will be secured, retrained and operated in the United States outside of ByteDance's control." 

    "TikTok's content-recommendation algorithm will be retrained from the ground up - reviewed and analyzed under U.S. supervision with U.S. data that will not be shared outside of the United States," the official said.

    This is an important point because U.S. officials had warned in recent years that the algorithm could be used by China to manipulate what Americans see on social media. Reuters and others reported this week that the algorithm could be licensed from ByteDance. 

    The official said U.S. users would still be able to use TikTok to interact with content from around the world. 

    TikTok's U.S. assets would be majority-owned by American investors and operated in the United States by a board of directors with national security and cybersecurity credentials, the official added. 

    ByteDance's current shareholders include Susquehanna International Group, General Atlantic, and KKR. ByteDance would hold less than 20% of the stock of a joint venture controlling TikTok's U.S. operations, the official said.

    Source: Reuters; Reporting by Jeff Mason and David Shepardson; Additional reporting by Clare Jim in Hong Kong; Writing by Jason Lange; Editing by Chris Sanders, Mary Milliken, Leslie Adler, David Gregorio and William Mallard   September 21, 20251:49 AM PDTUpdated 1 hour ago

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  9. (China Daily) Beijing-based biotech unicorn METiS TechBio has rolled out what it calls the world's first AI-powered nano-delivery platform, NanoForge, which could reshape the way medicines are developed and delivered, paving the way for reprogrammable drugs.  

    At the launch event in Beijing on Tuesday, cofounder and CEO Chris Lai compared the breakthrough to aerospace engineering. "NanoForge is like the SpaceX of drug delivery. It is both the rocket that delivers drugs precisely and the satellite that speeds up new drug development. This could solve one of the toughest problems in medicine, which is to get treatments exactly where they need to go, without harming healthy tissue," Lai said.  

    Drug delivery has long been one of the industry's hardest puzzles. The rollout of mRNA COVID-19 vaccines in 2020 showed the promise of lipid nanoparticle systems. These microscopic fat droplets can shield fragile molecules like mRNA and ferry them through the body. But applying them across multiple organs and scaling them for broader drug innovation have remained elusive.

    Lai explained that traditional drug delivery research relies heavily on trial and error, a slow and costly process with low success rates. For example, scientists may have to sift through tens of thousands of lipid combinations to identify a single viable LNP formula.  

    NanoForge uses a generative AI model called PhatGPT, which designs new lipid molecules atom by atom, much like ChatGPT generates text word by word. It evaluates multiple parameters at once to optimize performance, then validates results through automated lab experiments. "For nucleic acid drugs, NanoForge significantly improves mRNA encapsulation and targeting. What once required screening tens of thousands of formulas can now be achieved in weeks," said Zhang Xiaoju, head of RNA innovation at METiS.  

    METiS has developed three core solutions: AiLNP for nucleic acid delivery, AiRNA for mRNA sequence design and AiTEM for small-molecule drug formulation.

    So far, the company says Nano-Forge has produced more than 10 million lipid structures and collected around 100,000 data points to train its models. The platform has already shown targeted delivery in eight types of human organs and tissues, including the liver, lungs, tumors and the central nervous system.  

    To secure its edge, METiS has filed or obtained more than 100 patents.  

    Its drug pipeline includes more than 10 advanced programs. Seven have been validated in preclinical studies, while four are already in clinical trials. The lead candidate, an oncology therapy, has reached the pre-NDA stage, that is the final step before applying for regulatory approval.

    Drug development usually drags on for more than a decade and can cost upward of $1 billion. Founded in 2020, METiS seems to have broken that cycle, moving more than 10 programs into advanced stages within five years by combining AI with nanotechnology.  

    Still, experts urge caution. "The ultimate goal of innovative drug development is to address unmet clinical needs, deliver strong efficacy and safety data in trials, and secure regulatory approval," said Fang Yang, executive director for healthcare and biotech at CEC Capital. "From that perspective, AI-driven drug platforms still need time and clinical validation."  

    Lai acknowledged that METiS is in a "critical stage, moving from pre-commercial to commercial", with the focus now on ensuring both the platform and its pipeline generate sustained value.

    The business case appears compelling. According to consulting company Frost & Sullivan, the global market for intelligent drug-delivery solutions exceeded $18 billion in 2023 and will reach $52 billion by 2030, growing at a compound annual rate of 17.2 percent. Nano-delivery technologies are expected to make up 42 percent of that market by 2025, or roughly $7.8 billion, underscoring its growing importance in the field.  

    Investor interest has followed. In August, METiS closed a 400 million yuan ($55.6 million) Series D financing round. The fresh capital will support upgrades for NanoForge, pipeline expansion, global partnerships and new talent recruitment.

    Source: By Li Jing | China Daily | Updated: 2025-09-19 09:09

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  10. (Xinhua) In cancer immunotherapy, immune cells inside the body need to receive strong and enough "signals" to attack cancer cells. However, cancer cells are adept at disguising themselves, with very sparse natural signals on their surfaces.  

    To accurately identify cancer cells, a research team led by Han Shuo from the Center for Excellence in Molecular Cell Science at the Chinese Academy of Sciences has applied proximity labeling technology from chemical biology research to disease treatment.  

    They have successfully constructed an engineered nanozyme that responds to deep-red light or ultrasound, which is described as a "nano-tagging robot" that can precisely identify cancer cells, according to Han.  

    The nanozyme can carry antibodies or ligands that recognize cancer cells, and enrich on the surface of cancer cells through blood circulation. By giving instructions through deep-red light or ultrasound, it can clearly tag cancer cells, turning them into targets.

    The researchers also injected a specially-made BiTE molecule into mice in experiments, which can not only highlight the targets, but also activate immune T cells to join the fight against cancer.  

    "This tagging can also activate the whole-body immune system to form long-term memory, as if a 'tumor vaccine' has been administered in the body," said Han.  

    The study has achieved good therapeutic effects in both experimental mouse tumor models and in vitro clinical tumor samples. It is expected to pave a new path for the development of smarter and more efficient next-generation immunotherapies, according to Han.  

    Their study was published Wednesday online in the journal Nature. 

    Source: Xinhua  Published: 21:49, September 12, 2025

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